Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
نویسندگان
چکیده
منابع مشابه
Methylene blue for MDI.
Bryer JB, Borrelli D J, Matthews EJ Jr, Kornetsky C (1983): The psychological correlates of the DST in depressed patients. Psychopharmacol Bull 19:633-637. Carroll B, Feinberg M, Greden J, et al (1981): A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38:15-22. Nelson WH, Khan A, Orr WW Jr, Tamragouri RN (1984): The dexamethasone suppression test: Interaction of ...
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In this work the data of methylene blue (MB) and Hoechst 33258 interaction with DNA are presented. It has been shown that at 0.002 M ionic strength of solution MB is bound to double-stranded DNA by three modes: intercalation, semi-intercalation and electrostatic. It was revealed that at higher ionic strengths of solution complete intercalation of MB becomes thermodynamically unacceptable. It wa...
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The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many o...
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We investigated whether postextinction administration of methylene blue (MB) could enhance retention of an extinguished conditioned response. MB is a redox compound that at low doses elevates cytochrome oxidase activity, thereby improving brain energy production. Saline or MB (4 mg/kg intraperitoneally) were administered to rats for 5 d following extinction training of tone-footshock conditioni...
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Methylene blue is a safe and effective therapeutic agent used in a variety of different clinical settings, including as treatment for methemoglobinemia, reversing ifosfamide-induced encephalopa-thy, severe hepatopulmonary syndrome, and as a pressor during catecholamine-refractory septic shock (1). Of more relevance to neuropathologists, it has recently been experimentally tested as a dye in mul...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2012
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2011.10.007